# MYO18A

Source: https://onco.cc/targets/myo18a/  
OnCo record `myo18a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.

## Summary

Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.63, affected pathway 0.97, genetic association 0.00, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: myosin XVIIIA; Putative TGFB1-induced anti-apoptotic factor 1; KIAA0216; MysPDZ; TIAF1
- Tags: cancer-genes-wave
- Symbol: MYO18A
- Class: other
- Biology: Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).
- Where found: Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:31104: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31104
- UniProt O95411: https://www.uniprot.org/uniprotkb/O95411/entry
- NCBI Gene 399687: https://www.ncbi.nlm.nih.gov/gene/399687
- Ensembl ENSG00000196535: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196535

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/)

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JSON: https://onco.cc/api/v1/entities/myo18a.json