# MYSM1

Source: https://onco.cc/targets/mysm1/  
OnCo record `mysm1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MYSM1 (Deubiquitinase MYSM1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.

## Summary

Metalloprotease with deubiquitinase activity that plays important regulator roles in haematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Myb like, SWIRM and MPN domains 1; Deubiquitinase MYSM1; KIAA1915
- Tags: cancer-genes-wave
- Symbol: MYSM1
- Class: transcription
- Biology: Metalloprotease with deubiquitinase activity that plays important regulator roles in haematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signalling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. Location: Nucleus; Cytoplasm (UniProt). Locus 1p32.1 (HGNC).
- Where found: Myelodysplastic syndromes / neoplasms: Open Targets association 0.56 with myelodysplastic syndrome (MONDO_0018881)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29401: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29401
- UniProt Q5VVJ2: https://www.uniprot.org/uniprotkb/Q5VVJ2/entry
- NCBI Gene 114803: https://www.ncbi.nlm.nih.gov/gene/114803
- Ensembl ENSG00000162601: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162601

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)

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JSON: https://onco.cc/api/v1/entities/mysm1.json