# N4BP2

Source: https://onco.cc/targets/n4bp2/  
OnCo record `n4bp2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

N4BP2 (NEDD4-binding protein 2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Bladder & urothelial cancer and Biliary tract cancer.

## Summary

Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.

IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Cholangiocarcinoma, Hepatocellular Carcinoma, Upper Tract Urothelial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NEDD4 binding protein 2; NEDD4-binding protein 2; B3BP
- Tags: cancer-genes-wave
- Symbol: N4BP2
- Class: enzyme
- Biology: Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon. Location: Cytoplasm (UniProt). Locus 4p14 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC); Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29851: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29851
- UniProt Q86UW6: https://www.uniprot.org/uniprotkb/Q86UW6/entry
- NCBI Gene 55728: https://www.ncbi.nlm.nih.gov/gene/55728
- Ensembl ENSG00000078177: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078177

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/n4bp2.json