# NAB2

Source: https://onco.cc/targets/nab2/  
OnCo record `nab2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.54, genetic association 0.00, somatic mutation 0.89).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NGFI-A binding protein 2; NGFI-A-binding protein 2; MADER
- Tags: cancer-genes-wave
- Symbol: NAB2
- Class: transcription
- Biology: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Location: Nucleus (UniProt). Locus 12q13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7627: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7627
- UniProt Q15742: https://www.uniprot.org/uniprotkb/Q15742/entry
- NCBI Gene 4665: https://www.ncbi.nlm.nih.gov/gene/4665
- Ensembl ENSG00000166886: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166886

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/nab2.json