# NAF1

Source: https://onco.cc/targets/naf1/  
OnCo record `naf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.43, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear assembly factor 1 ribonucleoprotein; H/ACA ribonucleoprotein complex non-core subunit NAF1
- Tags: cancer-genes-wave
- Symbol: NAF1
- Class: other
- Biology: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Location: Cytoplasm; Nucleus (UniProt). Locus 4q32.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25126: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25126
- UniProt Q96HR8: https://www.uniprot.org/uniprotkb/Q96HR8/entry
- NCBI Gene 92345: https://www.ncbi.nlm.nih.gov/gene/92345
- Ensembl ENSG00000145414: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145414

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/naf1.json