# NAPRT

Source: https://onco.cc/targets/naprt/  
OnCo record `naprt` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NAPRT (Nicotinate phosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming GNE-617.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nicotinate phosphoribosyltransferase; Nicotinate phosphoribosyltransferase; PP3856; NAPRT1
- Tags: cancer-genes-wave
- Symbol: NAPRT
- Class: enzyme
- Biology: Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. Location: Cytoplasm, cytosol (UniProt). Locus 8q24.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30450: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30450
- UniProt Q6XQN6: https://www.uniprot.org/uniprotkb/Q6XQN6/entry
- NCBI Gene 93100: https://www.ncbi.nlm.nih.gov/gene/93100
- Ensembl ENSG00000147813: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147813

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/naprt.json