# Nature Genetics

Source: https://onco.cc/journals/nature-genetics/  
OnCo record `nature-genetics` (Journal). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Nature Genetics is the top genetics journal, publishing cancer genome-wide association studies, polygenic risk scores, cancer gene discovery and mutational-signature work.

## Summary

Nature Genetics (Nat Genet) is the leading genetics journal, founded in 1992, appearing monthly and published by Springer Nature on a hybrid access model. It publishes germline cancer susceptibility genome-wide association studies and polygenic risk models, somatic driver-gene discovery and mutational-signature analyses, tumour evolution and single-cell genomics methods. Its readers are cancer geneticists and genomics researchers, and the Mutational signature entry in OnCo draws on the kind of work it publishes. Within OnCo it is linked from the biographies of Mu-Sheng Zeng, Malachi Griffith, Obi Griffith, Cheryl Willman, Christina Curtis and Rebecca Fitzgerald, and a reader would use it for cancer gene discovery, polygenic risk and mutational-signature papers.

## Fields

- Kind: Journal
- Last checked: 2026-09-09
- Also known as: Nat Genet
- Publisher: Springer Nature
- Scope: genetics
- Access: hybrid

## Sources

- Nature Portfolio: https://www.nature.com

## Connected records

- terms: [Mutational signature](https://onco.cc/terms/mutational-signature/)
- key papers: [A Big Bang model of human colorectal tumor growth](https://onco.cc/key-papers/paper-sottoriva-nat-genet/), [Cancer therapy shapes the fitness landscape of clonal hematopoiesis](https://onco.cc/key-papers/paper-bolton-nat-genet/), [CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer](https://onco.cc/key-papers/paper-griffith-nat-genet/), [Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing](https://onco.cc/key-papers/paper-cortes-ciriano-nat-genet/), [CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer](https://onco.cc/key-papers/paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006/), [Deregulation of the platelet-derived growth factor B-chain gene via fusion with COL1A1 in dermatofibrosarcoma protuberans](https://onco.cc/key-papers/paper-simon-col1a1-pdgfb-dfsp-nat-genet-1997/), [Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas](https://onco.cc/key-papers/paper-campbell-pan-lung-somatic-alterations-nat-genet-2016/), [Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas](https://onco.cc/key-papers/paper-brastianos-nat-genet/), [Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer](https://onco.cc/key-papers/paper-barbieri-spop-foxa1-med12-prostate-nat-genet-2012/), [Genome doubling shapes the evolution and prognosis of advanced cancers](https://onco.cc/key-papers/paper-bielski-nat-genet/), [Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma](https://onco.cc/key-papers/paper-bonilla-nat-genet/), [Genomic and evolutionary classification of lung cancer in never smokers](https://onco.cc/key-papers/paper-zhang-lung-cancer-never-smokers-nat-genet-2021/), [Genomic landscape of lung adenocarcinoma in East Asians](https://onco.cc/key-papers/paper-chen-east-asian-lung-adenocarcinoma-nat-genet-2020/), [Genomic spectra of biliary tract cancer](https://onco.cc/key-papers/paper-nakamura-biliary-genomic-spectra-nat-genet-2015/), [Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas](https://onco.cc/key-papers/paper-palles-germline-pole-pold1-proofreading-nat-genet-2013/), [Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1](https://onco.cc/key-papers/paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009/), [Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands](https://onco.cc/key-papers/paper-anthony-nichols-nat-genet-2014/), [Identification of SYT and SSX, the genes fused by the t(X;18) translocation in synovial sarcoma](https://onco.cc/key-papers/paper-clark-syt-ssx-synovial-sarcoma-nat-genet-1994/), [Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas](https://onco.cc/key-papers/paper-anthony-nichols-nat-genet-2017/), [In vivo amplification of the androgen receptor gene and progression of human prostate cancer](https://onco.cc/key-papers/paper-visakorpi-androgen-receptor-amplification-nat-genet-1995/), [Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer](https://onco.cc/key-papers/paper-makohon-moore-metastases-driver-homogeneity-nat-genet-2017/), [Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases](https://onco.cc/key-papers/paper-hu-nat-genet/), [PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumours](https://onco.cc/key-papers/paper-lee-prc2-mpnst-nat-genet-2014/), [Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation](https://onco.cc/key-papers/paper-linder-nat-genet/), [Stromal contribution to the colorectal cancer transcriptome](https://onco.cc/key-papers/paper-isella-stromal-contribution-colorectal-transcriptome-nat-genet-2015/), [Stromal gene expression defines poor-prognosis subtypes in colorectal cancer](https://onco.cc/key-papers/paper-calon-stromal-gene-expression-poor-prognosis-colorectal-nat-genet-2015/), [Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy](https://onco.cc/key-papers/paper-barretina-nat-genet/), [The long tail of oncogenic drivers in prostate cancer](https://onco.cc/key-papers/paper-armenia-long-tail-oncogenic-drivers-prostate-nat-genet-2018/), [The t(11;19) translocation in mucoepidermoid carcinoma creates a CRTC1-MAML2 fusion](https://onco.cc/key-papers/paper-tonon-crtc1-maml2-nat-genet-2003/), [Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction](https://onco.cc/key-papers/paper-conti-trans-ancestry-gwas-prostate-nat-genet-2021/), [Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution](https://onco.cc/key-papers/paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020/), [Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma](https://onco.cc/key-papers/paper-moffitt-virtual-microdissection-subtypes-nat-genet-2015/), [Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway](https://onco.cc/key-papers/paper-li-gallbladder-exome-erbb-nat-genet-2014/)
- people: [Cheryl L. Willman](https://onco.cc/people/cheryl-willman/), [Christina Curtis](https://onco.cc/people/christina-curtis/), [Malachi Griffith](https://onco.cc/people/malachi-griffith/), [Matthew Hurles](https://onco.cc/people/matthew-hurles/), [Mu-Sheng Zeng](https://onco.cc/people/zeng-mu-sheng/), [Obi L. Griffith](https://onco.cc/people/obi-griffith/), [Rebecca C. Fitzgerald](https://onco.cc/people/rebecca-fitzgerald/)

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JSON: https://onco.cc/api/v1/entities/nature-genetics.json