# NBEA

Source: https://onco.cc/targets/nbea/  
OnCo record `nbea` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NBEA (Neurobeachin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Breast cancer, Colorectal cancer and 5 more.

## Summary

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.16, animal model 0.41, genetic association 0.62, somatic mutation 0.74). IntOGen calls it a driver in 14 cohorts (6 activating, 8 loss-of-function), covering Invasive Breast Carcinoma, Cervical Adenocarcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: neurobeachin; Neurobeachin; KIAA1544; BCL8B; FLJ10197; LYST2
- Tags: cancer-genes-wave
- Symbol: NBEA
- Class: tumor-suppressor
- Biology: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Location: Cytoplasm; Membrane (UniProt). Locus 13q13.3 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 3 cohorts (HCC); Breast cancer: IntOGen driver in 2 cohorts (BRCA); Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD); Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT); Cervical cancer: IntOGen driver in 1 cohort (CEAD); Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 6 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 8 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7648: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7648
- UniProt Q8NFP9: https://www.uniprot.org/uniprotkb/Q8NFP9/entry
- NCBI Gene 26960: https://www.ncbi.nlm.nih.gov/gene/26960
- Ensembl ENSG00000172915: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172915

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Cervical cancer](https://onco.cc/cancers/cervical/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/nbea.json