# NCAPH

Source: https://onco.cc/targets/ncaph/  
OnCo record `ncaph` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NCAPH (Condensin complex subunit 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.

## Summary

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: non-SMC condensin I complex subunit H; Condensin complex subunit 2; CAP-H; hCAP-H; NCAPH1; BRRN1
- Tags: cancer-genes-wave
- Symbol: NCAPH
- Class: oncogene
- Biology: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Location: Nucleus; Cytoplasm; Chromosome (UniProt). Locus 2q11.2 (HGNC).
- Where found: Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1112: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1112
- UniProt Q15003: https://www.uniprot.org/uniprotkb/Q15003/entry
- NCBI Gene 23397: https://www.ncbi.nlm.nih.gov/gene/23397
- Ensembl ENSG00000121152: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121152

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/ncaph.json