# NCKIPSD

Source: https://onco.cc/targets/nckipsd/  
OnCo record `nckipsd` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.

## Summary

Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NCK interacting protein with SH3 domain; NCK-interacting protein with SH3 domain; AF3P21; SPIN90; ORF1; WASLBP; DIP1
- Tags: cancer-genes-wave
- Symbol: NCKIPSD
- Class: tumor-suppressor
- Biology: Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerisation and cell adhesion. Plays a role in angiogenesis. Location: Nucleus (UniProt). Locus 3p21.31 (HGNC).
- Where found: Endometrial cancer: IntOGen driver in 1 cohort (UCEC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:15486: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15486
- UniProt Q9NZQ3: https://www.uniprot.org/uniprotkb/Q9NZQ3/entry
- NCBI Gene 51517: https://www.ncbi.nlm.nih.gov/gene/51517
- Ensembl ENSG00000213672: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213672

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/)

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JSON: https://onco.cc/api/v1/entities/nckipsd.json