# NCOA1

Source: https://onco.cc/targets/ncoa1/  
OnCo record `ncoa1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NCOA1 (Nuclear receptor coactivator 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, animal model 0.44, genetic association 0.47, somatic mutation 0.59). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear receptor coactivator 1; Nuclear receptor coactivator 1; SRC1; F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74
- Tags: cancer-genes-wave
- Symbol: NCOA1
- Class: transcription
- Biology: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Location: Nucleus (UniProt). Locus 2p23.3 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7668: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7668
- UniProt Q15788: https://www.uniprot.org/uniprotkb/Q15788/entry
- NCBI Gene 8648: https://www.ncbi.nlm.nih.gov/gene/8648
- Ensembl ENSG00000084676: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000084676

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/ncoa1.json