# NCOA3

Source: https://onco.cc/targets/ncoa3/  
OnCo record `ncoa3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NCOA3 (Nuclear receptor coactivator 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Colorectal cancer.

## Summary

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).

CIViC holds 3 clinical evidence items and 0 assertions across 3 variants, naming PD-1 Ligand Inhibitor and Anti-PDL1 Therapy.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear receptor coactivator 3; Nuclear receptor coactivator 3; RAC3; AIB1; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; bHLHe42; SRC-3; SRC3
- Tags: cancer-genes-wave
- Symbol: NCOA3
- Class: transcription
- Biology: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.12 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease; Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7670: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7670
- UniProt Q9Y6Q9: https://www.uniprot.org/uniprotkb/Q9Y6Q9/entry
- NCBI Gene 8202: https://www.ncbi.nlm.nih.gov/gene/8202
- Ensembl ENSG00000124151: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124151

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/ncoa3.json