# Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia

Source: https://onco.cc/trials/nct00002658/  
OnCo record `nct00002658` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Filgrastim, Amsacrine, Cyclophosphamide, Cytarabine, Daunorubicin, Etoposide, Idarubicin, Mitoxantrone, Thioguanine and Tretinoin in Leukaemia, run by Medical Research Council, with a status the registry has not verified recently.

## Summary

Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia is a phase 3 interventional study registered as NCT00002658 by Medical Research Council, with 2000 participants planned, started 1994-01. Interventions recorded: filgrastim, amsacrine, cyclophosphamide, cytarabine, daunorubicin hydrochloride, etoposide, idarubicin, mitoxantrone hydrochloride, thioguanine, tretinoin, allogeneic bone marrow transplantation, autologous bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy. Conditions recorded: Leukemia, Neutropenia.

Linked to the drug Amsacrine because the registry names it among its interventions and Leukaemia among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00002658
- Phase: 3
- Setting: ACUTE MYELOID LEUKAEMIA TRIAL 12
- Sponsor: Medical Research Council
- Enrolled: 2000

## Sources

- ClinicalTrials.gov NCT00002658: https://clinicaltrials.gov/study/NCT00002658

## Connected records

- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/)
- drugs: [Amsacrine](https://onco.cc/drugs/amsacrine/), [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Cytarabine](https://onco.cc/drugs/cytarabine/), [Daunorubicin](https://onco.cc/drugs/daunorubicin/), [Etoposide](https://onco.cc/drugs/etoposide/), [Filgrastim (G-CSF)](https://onco.cc/drugs/filgrastim/), [Idarubicin](https://onco.cc/drugs/idarubicin/), [Mitoxantrone](https://onco.cc/drugs/mitoxantrone/), [Thioguanine](https://onco.cc/drugs/thioguanine/), [Tretinoin (all-trans retinoic acid, ATRA)](https://onco.cc/drugs/tretinoin-atra/)

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