# Tyrosinase-specific CD8+ T cells, gene-modified and unmodified, in metastatic melanoma (Fred Hutchinson phase 1/2)

Source: https://onco.cc/trials/nct00002786/  
OnCo record `nct00002786` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

An early Seattle trial that gave people with melanoma that had spread their own T cells grown to recognise tyrosinase, a melanoma protein. It started in 1995 and the registry lists it as completed in 2006.

## Summary

The registry's official title is a phase I study of cellular adoptive immunotherapy using genetically modified and unmodified autologous CD8+ tyrosinase-specific T cells for patients with metastatic melanoma; the record lists it as phase 1/2, started in October 1995 and completed in March 2006, with an estimated enrolment of 20 (ClinicalTrials.gov NCT00002786). Cassian Yee is listed as study chair, the sponsor is Fred Hutchinson Cancer Center with the National Cancer Institute as collaborator, and the interventions are aldesleukin and therapeutic T cells (ClinicalTrials.gov NCT00002786). No results are posted.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-11-05
- Registry id: NCT00002786
- Phase: 1/2
- Setting: Metastatic melanoma: autologous CD8+ tyrosinase-specific T cells, genetically modified and unmodified, with aldesleukin
- Sponsor: Fred Hutchinson Cancer Center, with the National Cancer Institute
- Result: No results posted on ClinicalTrials.gov.

## Sources

- ClinicalTrials.gov NCT00002786: https://clinicaltrials.gov/study/NCT00002786

## Connected records

- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)
- targets: [TYR](https://onco.cc/targets/tyr/)
- drugs: [Aldesleukin (high-dose IL-2)](https://onco.cc/drugs/aldesleukin/)
- institutions: [Fred Hutchinson Cancer Center](https://onco.cc/institutions/fred-hutch/), [National Cancer Institute (NIH)](https://onco.cc/institutions/nci/)
- terms: [Endogenous T-cell therapy](https://onco.cc/terms/endogenous-t-cell-therapy/)
- people: [Cassian Yee](https://onco.cc/people/cassian-yee/)

---
JSON: https://onco.cc/api/v1/entities/nct00002786.json