# Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer

Source: https://onco.cc/trials/nct00003139/  
OnCo record `nct00003139` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Pilocarpine in Head and neck squamous cell carcinoma, run by Radiation Therapy Oncology Group, completed.

## Summary

Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer is a phase 3 interventional study registered as NCT00003139 by Radiation Therapy Oncology Group, with 249 participants recorded, started 1998-03 and reaching its primary completion in 2001-01. Interventions recorded: pilocarpine hydrochloride, Placebo. Conditions recorded: Head and Neck Cancer, Oral Complications.

Linked to the drug Pilocarpine because the registry names it among its interventions and Head and neck squamous cell carcinoma among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00003139
- Phase: 3
- Setting: A Phase III Study to Test the Efficacy of the Prophylactic Use of Oral Pilocarpine to Reduce Hyposalivation and Mucositis Associated With Curative Radiation Therapy in Head and Neck Cancer Patients
- Sponsor: Radiation Therapy Oncology Group
- Enrolled: 249

## Sources

- ClinicalTrials.gov NCT00003139: https://clinicaltrials.gov/study/NCT00003139

## Connected records

- cancers: [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/)
- drugs: [Pilocarpine](https://onco.cc/drugs/pilocarpine/)

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