# Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia

Source: https://onco.cc/trials/nct00003436/  
OnCo record `nct00003436` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Amsacrine, Asparaginase, Cytarabine, Daunorubicin, Etoposide, Methotrexate and Mitoxantrone in Leukaemia and Myelodysplastic syndromes / neoplasms, run by Medical Research Council, completed.

## Summary

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia is a phase 3 interventional study registered as NCT00003436 by Medical Research Council, with 2000 participants recorded, started 1998-07. Interventions recorded: amsacrine, asparaginase, cytarabine, daunorubicin hydrochloride, etoposide, methotrexate, mitoxantrone hydrochloride, therapeutic hydrocortisone, allogeneic bone marrow transplantation. Conditions recorded: Leukemia, Myelodysplastic Syndromes.

Linked to the drug Amsacrine because the registry names it among its interventions and Leukaemia and Myelodysplastic syndromes / neoplasms among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00003436
- Phase: 3
- Setting: Medical Research Council Working Party on Leukaemia in Childhood Acute Myeloid Leukaemia Trial 12
- Sponsor: Medical Research Council
- Enrolled: 2000

## Sources

- ClinicalTrials.gov NCT00003436: https://clinicaltrials.gov/study/NCT00003436

## Connected records

- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)
- drugs: [Amsacrine](https://onco.cc/drugs/amsacrine/), [Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase)](https://onco.cc/drugs/asparaginase/), [Cytarabine](https://onco.cc/drugs/cytarabine/), [Daunorubicin](https://onco.cc/drugs/daunorubicin/), [Etoposide](https://onco.cc/drugs/etoposide/), [Methotrexate](https://onco.cc/drugs/methotrexate/), [Mitoxantrone](https://onco.cc/drugs/mitoxantrone/)

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