# Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer

Source: https://onco.cc/trials/nct00004054/  
OnCo record `nct00004054` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Bicalutamide, Estramustine, Etoposide, Flutamide and Paclitaxel / nab-paclitaxel in Prostate cancer, run by Radiation Therapy Oncology Group, completed.

## Summary

Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer is a phase 3 interventional study registered as NCT00004054 by Radiation Therapy Oncology Group, with 397 participants recorded, started 2000-01 and reaching its primary completion in 2010-04. Interventions recorded: bicalutamide, estramustine phosphate sodium, etoposide, flutamide, paclitaxel, Luteinizing hormone releasing hormone [LHRH] agonist, Radiation therapy, warfarin. Conditions recorded: Prostate Cancer.

Linked to the drug Estramustine because the registry names it among its interventions and Prostate cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00004054
- Phase: 3
- Setting: A Phase III Protocol of Androgen Suppression (AS) and Radiation Therapy (RT) vs AS and RT Followed by Chemotherapy With Paclitaxel, Estramustine, and Etoposide (TEE) for Localized, High-Risk, Prostate Cancer
- Sponsor: Radiation Therapy Oncology Group
- Enrolled: 397

## Sources

- ClinicalTrials.gov NCT00004054: https://clinicaltrials.gov/study/NCT00004054

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- drugs: [Bicalutamide](https://onco.cc/drugs/bicalutamide/), [Estramustine](https://onco.cc/drugs/estramustine/), [Etoposide](https://onco.cc/drugs/etoposide/), [Flutamide](https://onco.cc/drugs/flutamide/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/)

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