# Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery

Source: https://onco.cc/trials/nct00005838/  
OnCo record `nct00005838` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Shark cartilage in Lung cancer and Non-small-cell lung cancer, run by National Cancer Institute (NCI), completed.

## Summary

Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery is a phase 3 interventional study registered as NCT00005838 by National Cancer Institute (NCI), with 756 participants recorded, started 2000-03 and reaching its primary completion in 2007-02. Interventions recorded: shark cartilage extract AE-941, placebo, cisplatin, vinorelbine tartrate, carboplatin, paclitaxel, radiation therapy. Conditions recorded: Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Squamous Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer.

Linked to the technology Shark cartilage because the registry names it ("shark cartilage") among its interventions and Lung cancer and Non-small-cell lung cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00005838
- Phase: 3
- Setting: Multicenter, Open-Ended, Double-Blind, Placebo-Controlled, Phase III Study of AE-941 in Addition to Combined Modality Treatment (Chemotherapy/Radiotherapy) for Locally Advanced Unresectable Non-Small Cell Lung Cancer
- Sponsor: National Cancer Institute (NCI)
- Enrolled: 756

## Sources

- ClinicalTrials.gov NCT00005838: https://clinicaltrials.gov/study/NCT00005838

## Connected records

- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [Shark cartilage (AE-941, Neovastat)](https://onco.cc/technologies/shark-cartilage/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Vinorelbine](https://onco.cc/drugs/vinorelbine/)

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JSON: https://onco.cc/api/v1/entities/nct00005838.json