# HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer

Source: https://onco.cc/trials/nct00412022/  
OnCo record `nct00412022` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Tamoxifen, Triptorelin, Letrozole and Zoledronic acid in Breast cancer, run by National Cancer Institute, Naples, with a status the registry has not verified recently.

## Summary

HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer is a phase 3 interventional study registered as NCT00412022 by National Cancer Institute, Naples, with 1294 participants planned, started 2004-03 and due to reach its primary completion in 2024-11. Interventions recorded: tamoxifen, triptorelin, letrozole, zoledronic acid. Conditions recorded: Breast Cancer.

Linked to the drug Triptorelin because the registry names it among its interventions and Breast cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00412022
- Phase: 3
- Setting: Phase III Randomized Study of the Effects on Bone Mineral Density of Tamoxifen, Letrozole, and Letrozole + Zoledronic Acid as Adjuvant Treatment of Patients With Early Breast Cancer; VERSION 2 AMENDED Phase 3 Study of Triptorelin and Tamoxifen, Letrozole, or Letrozole + Zoledronic Acid in Adjuvant Treatment of Premenopausal Endocrine Responsive Breast Cancer Patients.
- Sponsor: National Cancer Institute, Naples
- Enrolled: 1294

## Sources

- ClinicalTrials.gov NCT00412022: https://clinicaltrials.gov/study/NCT00412022

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Letrozole (and other aromatase inhibitors)](https://onco.cc/drugs/letrozole/), [Tamoxifen](https://onco.cc/drugs/tamoxifen/), [Triptorelin](https://onco.cc/drugs/triptorelin/), [Zoledronic acid](https://onco.cc/drugs/zoledronic-acid/)

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JSON: https://onco.cc/api/v1/entities/nct00412022.json