# G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct00541125/  
OnCo record `nct00541125` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of UGT1A1 genotyping before irinotecan in Colorectal cancer, run by Federation Francophone de Cancerologie Digestive, completed.

## Summary

G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal Cancer is a phase 2 interventional study registered as NCT00541125 by Federation Francophone de Cancerologie Digestive, with 20 participants recorded, started 2007-11 and reaching its primary completion in 2013-09. Interventions recorded: bevacizumab, filgrastim, fluorouracil, irinotecan hydrochloride, leucovorin calcium. Conditions recorded: Colorectal Cancer.

Linked to the technology UGT1A1 genotyping before irinotecan because the registry's title names it ("ugt1a1 28") and Colorectal cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00541125
- Phase: 2
- Setting: Phase II, Multicenter Study Evaluating G-CSF as Primary Prophylaxis for Neutropenia Associated With First-line Chemotherapy Regimen FOLFIRI and Bevacizumab in Patients With Metastatic Colorectal Cancer Who Are Homozygous for UGT1A1*28 Polymorphism, the Promoter of the Gene Encoding for the Enzyme UGT1A1
- Sponsor: Federation Francophone de Cancerologie Digestive
- Enrolled: 20

## Sources

- ClinicalTrials.gov NCT00541125: https://clinicaltrials.gov/study/NCT00541125

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- technologies: [UGT1A1 genotyping before irinotecan](https://onco.cc/technologies/ugt1a1-genotyping/)
- drugs: [Filgrastim (G-CSF)](https://onco.cc/drugs/filgrastim/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [Irinotecan (and liposomal irinotecan)](https://onco.cc/drugs/irinotecan/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)

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