# High Dose Methotrexate With Leucovorin Rescue With or Without Glucarpidase in Osteosarcoma

Source: https://onco.cc/trials/nct00634322/  
OnCo record `nct00634322` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Glucarpidase and Leucovorin in Osteosarcoma, run by BTG International Inc., recorded as terminated on the registry.

## Summary

High Dose Methotrexate With Leucovorin Rescue With or Without Glucarpidase in Osteosarcoma is a phase 2 interventional study registered as NCT00634322 by BTG International Inc., with 7 participants recorded, started 2008-10 and due to reach its primary completion in 2009-03. Interventions recorded: glucarpidase, leucovorin. Conditions recorded: Osteosarcoma.

Linked to the drug Glucarpidase because the registry names it among its interventions and Osteosarcoma among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT00634322
- Phase: 2
- Setting: Randomized, Blinded, Placebo-Controlled Trial of High Dose Methotrexate With Leucovorin Rescue (HDMTX-LV) With or Without Glucarpidase in Osteosarcoma
- Sponsor: BTG International Inc.
- Enrolled: 7

## Sources

- ClinicalTrials.gov NCT00634322: https://clinicaltrials.gov/study/NCT00634322

## Connected records

- cancers: [Osteosarcoma](https://onco.cc/cancers/osteosarcoma/)
- drugs: [Glucarpidase](https://onco.cc/drugs/glucarpidase/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)

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JSON: https://onco.cc/api/v1/entities/nct00634322.json