# LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis

Source: https://onco.cc/trials/nct02205762/  
OnCo record `nct02205762` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of Prednisone, Vinblastine, Mercaptopurine, Methotrexate, Cytarabine, Cladribine and Human normal immunoglobulin in Langerhans cell histiocytosis, run by North American Consortium for Histiocytosis, active and no longer recruiting.

## Summary

LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis is a phase 2/3 interventional study registered as NCT02205762 by North American Consortium for Histiocytosis, with 1400 participants planned, started 2016-11-02 and due to reach its primary completion in 2026-07. Interventions recorded: Prednisone, Vinblastine, mercaptopurine, INDOMETHACIN, Methotrexate, Cytosine Arabinoside, 2-chlorodeoxyadenosine, hematopoietic stem cell transplantation (RIC-HSCT), Intravenous immunoglobulin. Conditions recorded: Langerhans Cell Histiocytosis.

Linked to the drug Human normal immunoglobulin because the registry names it among its interventions and Langerhans cell histiocytosis among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT02205762
- Phase: 2/3
- Setting: LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
- Sponsor: North American Consortium for Histiocytosis
- Enrolled: 1400

## Sources

- ClinicalTrials.gov NCT02205762: https://clinicaltrials.gov/study/NCT02205762

## Connected records

- cancers: [Langerhans cell histiocytosis (LCH)](https://onco.cc/cancers/langerhans-cell-histiocytosis/)
- drugs: [Cladribine](https://onco.cc/drugs/cladribine/), [Cytarabine](https://onco.cc/drugs/cytarabine/), [Human normal immunoglobulin (IVIg)](https://onco.cc/drugs/human-normal-immunoglobulin/), [Mercaptopurine](https://onco.cc/drugs/mercaptopurine/), [Methotrexate](https://onco.cc/drugs/methotrexate/), [Prednisone](https://onco.cc/drugs/prednisone/), [Vinblastine](https://onco.cc/drugs/vinblastine/)

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