# Autologous CD4+ NY-ESO-1-specific T cells with ipilimumab in NY-ESO-1-expressing tumours (MD Anderson phase 1, withdrawn)

Source: https://onco.cc/trials/nct02210104/  
OnCo record `nct02210104` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A planned MD Anderson trial of helper T cells against the NY-ESO-1 protein, given with the immunotherapy drug ipilimumab, for melanoma and sarcoma. It was withdrawn before anyone joined.

## Summary

The registry describes a phase I study of autologous CD4+ NY-ESO-1-specific T cells with anti-CTLA-4 (ipilimumab) and cyclophosphamide for patients with NY-ESO-1-expressing tumours, listing melanoma and sarcoma as conditions (ClinicalTrials.gov NCT02210104). It was withdrawn with an actual enrolment of 0; the reason given is "Issues with tetramer staining" (ClinicalTrials.gov NCT02210104). Cassian Yee is listed as principal investigator; the record names NIH grant R01CA104711 (ClinicalTrials.gov NCT02210104).

## Fields

- Kind: Trial
- Status: withdrawn
- Last checked: 2026-11-05
- Tags: failure
- Registry id: NCT02210104
- Phase: 1
- Setting: NY-ESO-1-expressing melanoma or sarcoma: cyclophosphamide, autologous CD4+ NY-ESO-1-specific T cells and ipilimumab
- Sponsor: M.D. Anderson Cancer Center, with the National Institutes of Health and the National Cancer Institute
- Enrolled: 0
- Result: Withdrawn before enrolment (0 participants); registry reason: "Issues with tetramer staining".

## Sources

- ClinicalTrials.gov NCT02210104: https://clinicaltrials.gov/study/NCT02210104

## Connected records

- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)
- targets: [CTAG1B](https://onco.cc/targets/ctag1b/)
- drugs: [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Ipilimumab](https://onco.cc/drugs/ipilimumab/)
- institutions: [MD Anderson Cancer Center](https://onco.cc/institutions/md-anderson/), [National Cancer Institute (NIH)](https://onco.cc/institutions/nci/)
- terms: [Endogenous T-cell therapy](https://onco.cc/terms/endogenous-t-cell-therapy/)
- people: [Cassian Yee](https://onco.cc/people/cassian-yee/)

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JSON: https://onco.cc/api/v1/entities/nct02210104.json