# Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer

Source: https://onco.cc/trials/nct02448992/  
OnCo record `nct02448992` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in lung cancer, run by Chang Gung Memorial Hospital, now recruiting.

## Summary

Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer is a phase 2/3, randomised interventional study registered as NCT02448992 by Chang Gung Memorial Hospital, with a registry enrolment figure of 90 participants, started 2015-08-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: hippocampal-sparing WBRT. Conditions listed: Non-Small-Cell Lung Cancer (NSCLC); Brain Metastasis. Primary outcome: time to the development of brain metastasis/metastases (BM), irrespective of the absence of active neurological symptoms. Lung eligibility wording from the registry: "* Clinical diagnosis of NSCLC". Sites: Taiwan. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT02448992
- Phase: 2/3
- Setting: Neuropsychological and Oncological Outcomes After Hippocampal-Sparing Prophylactic Cranial Irradiation in Postoperative Patients With Pathologically Nodal Positive Non-Small-Cell Lung Cancer - A Prospective Follow-up Study
- Sponsor: Chang Gung Memorial Hospital
- Enrolled: 90

## Sources

- ClinicalTrials.gov NCT02448992: https://clinicaltrials.gov/study/NCT02448992

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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