# Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers

Source: https://onco.cc/trials/nct02497820/  
OnCo record `nct02497820` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of aspirin in colorectal cancer, run by Tel-Aviv Sourasky Medical Center, not yet recruiting.

## Summary

Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers is a phase 3, randomised interventional study registered as NCT02497820 by Tel-Aviv Sourasky Medical Center, with a registry enrolment figure of 1800 participants, started 2016-09 and due to reach its primary completion in 2027-09. Interventions recorded: Aspirin. Conditions listed: Lynch Syndrome I (Site-specific Colonic Cancer). Primary outcome: cancer preventive properties of enteric coated aspirin in Lynch syndrome are dose sensitive by comparing overall cumulative Lynch syndrome cancer. Sites: Israel. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: CaPP3 Israel
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT02497820
- Phase: 3
- Setting: A Randomised Double Blind Dose Non-inferiority Trial of a Daily Dose of 600mg Versus 300mg Versus 100mg of Enteric Coated Aspirin as a Cancer Preventive in Carriers of a Germline Pathological Mismatch Repair Gene Defect, Lynch Syndrome
- Sponsor: Tel-Aviv Sourasky Medical Center
- Enrolled: 1800

## Sources

- ClinicalTrials.gov NCT02497820: https://clinicaltrials.gov/study/NCT02497820

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/)
- drugs: [Aspirin](https://onco.cc/drugs/aspirin/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct02497820.json