# FOLFOX or CAPOX Perioperative Chemotherapy Versus Postoperative Chemotherapy for Locally Advanced Colon Cancer (OPTICAL)

Source: https://onco.cc/trials/nct02572141/  
OnCo record `nct02572141` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Sun Yat-sen University, active but no longer recruiting.

## Summary

FOLFOX or CAPOX Perioperative Chemotherapy Versus Postoperative Chemotherapy for Locally Advanced Colon Cancer (OPTICAL) is a phase 3, randomised interventional study registered as NCT02572141 by Sun Yat-sen University, with a registry enrolment figure of 738 participants, started 2015-01-01 and due to reach its primary completion in 2023-03-15. Interventions recorded: Perioperative chemotherapy with mFOLFOX6 or CAPOX regimens; Postoperative chemotherapy with mFOLFOX6 or CAPOX regimens. Conditions listed: Colon Cancer. Primary outcome: Disease-free survival. Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the colon (≥ 15 cm from the anal verge)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: OPTICAL
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT02572141
- Phase: 3
- Setting: A Phase III Study to Evaluate the 3-year Disease-free Survival in Patients With Locally Advanced Colon Cancer Receiving Either Perioperative or Postoperative Chemotherapy With FOLFOX or CAPOX Regimens
- Sponsor: Sun Yat-sen University
- Enrolled: 738

## Sources

- ClinicalTrials.gov NCT02572141: https://clinicaltrials.gov/study/NCT02572141

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct02572141.json