# Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases

Source: https://onco.cc/trials/nct02758951/  
OnCo record `nct02758951` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Koen Rovers, active but no longer recruiting.

## Summary

Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases is a phase 2/3, randomised interventional study registered as NCT02758951 by Koen Rovers, with a registry enrolment figure of 358 participants, started 2017-06-01 and due to reach its primary completion in 2024-10-31. Interventions recorded: Perioperative systemic therapy; Perioperative CAPOX-bevacizumab; Perioperative FOLFOX-bevacizumab; Perioperative FOLFIRI-bevacizumab; CRS-HIPEC, experimental arm; CRS-HIPEC, control arm. Conditions listed: Colorectal Neoplasm; Colorectal Cancer; Colorectal Neoplasms Malignant; Colorectal Carcinoma; Colorectal Adenocarcinoma; Peritoneal Neoplasms; Peritoneal Carcinomatosis; Peritoneal Cancer; Peritoneal Metastases; Peritoneal Neoplasm Malignant Secondary Carcinomatosis; Peritoneal Neoplasm Malignant Secondary. Primary outcome: Overall survival. Colorectal eligibility wording from the registry: "* histological or cytological proof of PM of a non-appendiceal colorectal adenocarcinoma with ≤50% of the tumour cells being signet ring cells;". Sites: Belgium, Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: CAIRO6
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT02758951
- Phase: 2/3
- Setting: Perioperative Systemic Therapy and Cytoreductive Surgery With HIPEC Versus Upfront Cytoreductive Surgery With HIPEC Alone for Isolated Resectable Colorectal Peritoneal Metastases: a Multicentre, Open-label, Parallel-group, Phase II-III, Randomised Superiority Study
- Sponsor: Koen Rovers
- Enrolled: 358

## Sources

- ClinicalTrials.gov NCT02758951: https://clinicaltrials.gov/study/NCT02758951

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [HIPEC / PIPAC (intraperitoneal chemotherapy)](https://onco.cc/technologies/hipec/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct02758951.json