# Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome

Source: https://onco.cc/trials/nct02813824/  
OnCo record `nct02813824` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Assistance Publique - Hôpitaux de Paris, active but no longer recruiting.

## Summary

Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome is a phase 3, randomised interventional study registered as NCT02813824 by Assistance Publique - Hôpitaux de Paris, with a registry enrolment figure of 852 participants, started 2017-11-14 and due to reach its primary completion in 2026-06-15. Interventions recorded: Acetylsalicylic acid lysinate 300 mg; Placebo (for Aspirin 300); Acetylsalicylic acid lysinate 100 mg; Placebo 100 (for Aspirin 100). Conditions listed: Lynch Syndrome. Primary outcome: Number of patients with at least one adenoma seen on chromo-endoscopy 48 months after complete withdrawal of polyps and initiation of treatment (aspirin or placebo). Colorectal eligibility wording from the registry: "* Aged more than 25 years, et aged more than 18 years with an early familial history and any reason to perform a colonoscopy every 2 years". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: AAS-Lynch
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT02813824
- Phase: 3
- Setting: Assessment of the Effect of a Daily Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome
- Sponsor: Assistance Publique - Hôpitaux de Paris
- Enrolled: 852

## Sources

- ClinicalTrials.gov NCT02813824: https://clinicaltrials.gov/study/NCT02813824

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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