# Olaparib with or without atezolizumab in BRCA-mutant breast cancer

Source: https://onco.cc/trials/nct02849496/  
OnCo record `nct02849496` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This study compares olaparib alone with olaparib plus atezolizumab in advanced BRCA-mutant breast cancer. It tests adding immune treatment to DNA-repair inhibition, rather than treatment after curative breast surgery.

## Summary

This study compares olaparib alone with olaparib plus atezolizumab in advanced BRCA-mutant breast cancer. It tests adding immune treatment to DNA-repair inhibition, rather than treatment after curative breast surgery.

Interventional study registered as NCT02849496, sponsored by National Cancer Institute (NCI). Registry phase: 2. Registry enrollment is 89 participants (actual). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-10-10
- Also known as: Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer
- Tags: ucsf-breast-coverage; interventional
- Registry id: NCT02849496
- Phase: 2
- Setting: BRCA-mutant, HER2-negative unresectable or metastatic breast cancer
- Sponsor: National Cancer Institute (NCI)
- Enrolled: 89

## Sources

- ClinicalTrials.gov NCT02849496: https://clinicaltrials.gov/study/NCT02849496
- UCSF study listing and local availability: https://clinicaltrials.ucsf.edu/trial/NCT02849496

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Atezolizumab](https://onco.cc/drugs/atezolizumab/), [Olaparib](https://onco.cc/drugs/olaparib/)
- institutions: [UCSF Helen Diller Family Comprehensive Cancer Center](https://onco.cc/institutions/ucsf/)

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