# Randomizing Two Radiotherapy Boost Options to Avoid Rectal Cancer Surgery

Source: https://onco.cc/trials/nct03051464/  
OnCo record `nct03051464` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Sir Mortimer B. Davis - Jewish General Hospital, now recruiting.

## Summary

Randomizing Two Radiotherapy Boost Options to Avoid Rectal Cancer Surgery is a phase 2/3, randomised interventional study registered as NCT03051464 by Sir Mortimer B. Davis - Jewish General Hospital, with a registry enrolment figure of 131 participants, started 2017-04-25 and due to reach its primary completion in 2028-01. Interventions recorded: Complete responders and Non-complete responders; Chemoradiation + EBRT Boost; Chemoradiation + HDRBT Boost. Conditions listed: Stage II Rectal Cancer; Organ Preservation; Non-operative Treatment; Rectal Cancer (Stage III); Rectal Cancer Patients. Primary outcome: TME-free survival. Colorectal eligibility wording from the registry: "* Rectal cancer patients, clinically staged as T2-T3a,b N0-1 by MRI or endoscopic/trans-rectal ultrasound". Sites: Canada, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: MORPHEUS
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03051464
- Phase: 2/3
- Setting: A Phase III Study Testing Two Dose Escalation Strategies to Increase the Population of Complete Responders After Radiation Therapy in the Context of Organ Preservation for Patients With Rectal Cancer
- Sponsor: Sir Mortimer B. Davis - Jewish General Hospital
- Enrolled: 131

## Sources

- ClinicalTrials.gov NCT03051464: https://clinicaltrials.gov/study/NCT03051464

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03051464.json