# Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents

Source: https://onco.cc/trials/nct03206671/  
OnCo record `nct03206671` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Cyclophosphamide, Cytarabine, Dexamethasone, Doxorubicin, Vindesine, Etoposide, Ifosfamide, Methotrexate, Prednisone and Vincristine in Non-Hodgkin lymphoma, run by University Hospital Muenster, active and no longer recruiting.

## Summary

Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents is a phase 3 interventional study registered as NCT03206671 by University Hospital Muenster, with 650 participants planned, started 2017-08-03 and due to reach its primary completion in 2027-06. Interventions recorded: Rituximab window, Additional doses of Rituximab, Cyclophosphamide, Cytarabine, Dexamethasone, Doxorubicin hydrochloride, Vindesine Sulfate, Etoposide, Ifosfamide, Methotrexate, Prednisolone, Vincristine. Conditions recorded: Mature B-cell Non-Hodgkin Lymphoma.

Linked to the drug Vindesine because the registry names it among its interventions and Non-Hodgkin lymphoma among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT03206671
- Phase: 3
- Setting: B-NHL 2013 - Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents
- Sponsor: University Hospital Muenster
- Enrolled: 650

## Sources

- ClinicalTrials.gov NCT03206671: https://clinicaltrials.gov/study/NCT03206671

## Connected records

- cancers: [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)
- drugs: [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Cytarabine](https://onco.cc/drugs/cytarabine/), [Dexamethasone](https://onco.cc/drugs/dexamethasone/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Etoposide](https://onco.cc/drugs/etoposide/), [Ifosfamide](https://onco.cc/drugs/ifosfamide/), [Methotrexate](https://onco.cc/drugs/methotrexate/), [Prednisone](https://onco.cc/drugs/prednisone/), [Vincristine](https://onco.cc/drugs/vincristine/), [Vindesine](https://onco.cc/drugs/vindesine/)

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JSON: https://onco.cc/api/v1/entities/nct03206671.json