# A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC

Source: https://onco.cc/trials/nct03303495/  
OnCo record `nct03303495` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC is a phase 3, randomised interventional study registered as NCT03303495 by Sun Yat-sen University, with a registry enrolment figure of 280 participants, started 2011-11-14 and due to reach its primary completion in 2026-12-31. Interventions recorded: Bevacizumab; CPT-11; 5-FU Bolus; 5-FU Infusion; l-LV (dl-LV). Conditions listed: Colorectal Neoplasms; Neoplasm Metastasis; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms. Primary outcome: Progression-free survival (PFS). Colorectal eligibility wording from the registry: "Histologically-confirmed inoperable colorectal adenocarcinoma excluding vermiform appendix cancer and anal canal cancer". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03303495
- Phase: 3
- Setting: A Multinational, Randomized, Phase III Study of FOLFIRI With/Without Bevacizumab Versus Irinotecan With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer
- Sponsor: Sun Yat-sen University
- Enrolled: 280

## Sources

- ClinicalTrials.gov NCT03303495: https://clinicaltrials.gov/study/NCT03303495

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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