# Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

Source: https://onco.cc/trials/nct03407144/  
OnCo record `nct03407144` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Pembrolizumab, Doxorubicin, Vinblastine in hodgkin lymphoma, run by Merck Sharp & Dohme LLC, active and no longer recruiting.

## Summary

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667) is a phase 2 interventional study registered as NCT03407144 by Merck Sharp & Dohme LLC, with 340 participants planned, started 2018-04-09 and due to reach its primary completion in 2026-11-06. Interventions recorded: pembrolizumab, doxorubicin, vinblastine, dacarbazine, cyclophosphamide. Conditions listed: Hodgkin Lymphoma. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT03407144
- Phase: 2
- Setting: An Open-label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults With Newly Diagnosed Classical Hodgkin Lymphoma With Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667)
- Sponsor: Merck Sharp & Dohme LLC
- Enrolled: 340

## Sources

- ClinicalTrials.gov NCT03407144: https://clinicaltrials.gov/study/NCT03407144

## Connected records

- cancers: [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/)
- drugs: [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Dacarbazine](https://onco.cc/drugs/dacarbazine/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Vinblastine](https://onco.cc/drugs/vinblastine/), [Vincristine](https://onco.cc/drugs/vincristine/)
- companies: [Merck & Co. (MSD)](https://onco.cc/companies/merck/)

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