# Second and Third Look Laparoscopy in pT4 Colon Cancer Patients for Early Detection of Peritoneal Metastases

Source: https://onco.cc/trials/nct03413254/  
OnCo record `nct03413254` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), active but no longer recruiting.

## Summary

Second and Third Look Laparoscopy in pT4 Colon Cancer Patients for Early Detection of Peritoneal Metastases is a phase 3, randomised interventional study registered as NCT03413254 by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), with a registry enrolment figure of 389 participants, started 2018-03-01 and due to reach its primary completion in 2025-03-01. Interventions recorded: Routine follow-up; Second look DLS; Third look DLS. Conditions listed: Colorectal Cancer; Peritoneal Metastases. Primary outcome: Proportion of peritoneal metastases detected after a negative second look DLS. Colorectal eligibility wording from the registry: "* Curative intent resection of pT4a,bN0-2M0 colon cancer or rectosigmoid cancer above the peritoneal reflection, with or without adjuvant systemic therapy;". Sites: Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: COLOPEC-II
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03413254
- Phase: 3
- Setting: Second and Third Look Laparoscopy in pT4 Colon Cancer Patients for Early Detection of Peritoneal Metastases; the COLOPEC-II Randomized Multicentre Trial
- Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Enrolled: 389

## Sources

- ClinicalTrials.gov NCT03413254: https://clinicaltrials.gov/study/NCT03413254

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Robotic & minimally invasive surgery](https://onco.cc/technologies/robotic-surgery/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03413254.json