# AVIATOR

Source: https://onco.cc/trials/nct03414658/  
OnCo record `nct03414658` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

AVIATOR compares trastuzumab and vinorelbine with combinations that add avelumab, with or without utomilumab. It asks whether the added immune treatments improve control of advanced HER2-positive breast cancer.

## Summary

AVIATOR compares trastuzumab and vinorelbine with combinations that add avelumab, with or without utomilumab. It asks whether the added immune treatments improve control of advanced HER2-positive breast cancer.

Interventional study registered as NCT03414658, sponsored by Adrienne G. Waks. Registry phase: 2. Registry enrollment is 100 participants (actual). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-10-10
- Also known as: The AVIATOR Study: Trastuzumab and Vinorelbine With Avelumab OR Avelumab & Utomilumab in Advanced HER2+ Breast Cancer
- Tags: ucsf-breast-coverage; interventional
- Registry id: NCT03414658
- Phase: 2
- Setting: Advanced HER2-positive breast cancer
- Sponsor: Adrienne G. Waks
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT03414658: https://clinicaltrials.gov/study/NCT03414658
- UCSF study listing and local availability: https://clinicaltrials.ucsf.edu/trial/NCT03414658

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Avelumab](https://onco.cc/drugs/avelumab/), [Trastuzumab](https://onco.cc/drugs/trastuzumab/), [Utomilumab](https://onco.cc/drugs/utomilumab/), [Vinorelbine](https://onco.cc/drugs/vinorelbine/)
- institutions: [UCSF Helen Diller Family Comprehensive Cancer Center](https://onco.cc/institutions/ucsf/)

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