# A Study Evaluating Intensive Chemotherapy With or Without Glasdegib or Azacitidine With or Without Glasdegib In Patients With Previously Untreated Acute Myeloid Leukemia

Source: https://onco.cc/trials/nct03416179/  
OnCo record `nct03416179` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Glasdegib, CPX-351, Azacitidine and Cytarabine in Leukaemia, run by Pfizer, completed.

## Summary

A Study Evaluating Intensive Chemotherapy With or Without Glasdegib or Azacitidine With or Without Glasdegib In Patients With Previously Untreated Acute Myeloid Leukemia is a phase 3 interventional study registered as NCT03416179 by Pfizer, with 730 participants recorded, started 2018-04-20 and reaching its primary completion in 2020-06-05. Interventions recorded: glasdegib, daunorubicin + cytarabine, azacitidine, Placebo, Placebo, glasdegib, cytarabine, HSCT. Conditions recorded: Leukemia, Myeloid, Acute.

Linked to the drug Glasdegib because the registry names it among its interventions and Leukaemia among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT03416179
- Phase: 3
- Setting: A RANDOMIZED (1:1), DOUBLE-BLIND, MULTI-CENTER, PLACEBO CONTROLLED STUDY EVALUATING INTENSIVE CHEMOTHERAPY WITH OR WITHOUT GLASDEGIB (PF-04449913) OR AZACITIDINE (AZA) WITH OR WITHOUT GLASDEGIB IN PATIENTS WITH PREVIOUSLY UNTREATED ACUTE MYELOID LEUKEMIA
- Sponsor: Pfizer
- Enrolled: 730

## Sources

- ClinicalTrials.gov NCT03416179: https://clinicaltrials.gov/study/NCT03416179

## Connected records

- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/)
- drugs: [Azacitidine](https://onco.cc/drugs/azacitidine/), [CPX-351 (liposomal daunorubicin-cytarabine)](https://onco.cc/drugs/cpx-351/), [Cytarabine](https://onco.cc/drugs/cytarabine/), [Glasdegib](https://onco.cc/drugs/glasdegib/)
- companies: [Pfizer (incl. Seagen)](https://onco.cc/companies/pfizer/)

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