# EPA for Metastasis Trial 2

Source: https://onco.cc/trials/nct03428477/  
OnCo record `nct03428477` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Mark A Hull, PhD FRCP, active but no longer recruiting.

## Summary

EPA for Metastasis Trial 2 is a phase 3, randomised interventional study registered as NCT03428477 by Mark A Hull, PhD FRCP, with a registry enrolment figure of 418 participants, started 2018-05-02 and due to reach its primary completion in 2025-11-30. Interventions recorded: Icosapent Ethyl; Placebo. Conditions listed: Liver Metastasis; Colon Cancer. Primary outcome: Progression Free Survival (PFS). Colorectal eligibility wording from the registry: "* Histological diagnosis of colorectal cancer with evidence of liver metastases". Sites: United Kingdom. United Kingdom sites listed: 13. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: EMT2
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03428477
- Phase: 3
- Setting: A Randomised Placebo-controlled Phase III Trial of the Effect of the Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) on Colorectal Cancer Recurrence and Survival After Surgery for Resectable Liver Metastases
- Sponsor: Mark A Hull, PhD FRCP
- Enrolled: 418

## Notes

- UK sites (registry): Oxford University Hospital NHS Foundation Trust (Oxford); Hampshire Hospitals NHS Foundation Trust (Basingstoke); Aintree University Hospitals NHS Foundation Trust (Aintree); University Hospitals Birmingham NHS Foundation Trust (Birmingham); Cambridge UniversityHospitals NHS Foundation Trust (Cambridge); University Hospital of Wales (Cardiff); Leeds Teaching Hospitals NHS Foundation Trust (Leeds); King's College London (London); Royal Free London NHS Foundation Trust (London); Newcastle Upon Tyne Hospitals NHS Foundation Trust (Newcastle); Nottingham University Hospitals NHS Trust (Nottingham); Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield) and 1 more.

## Sources

- ClinicalTrials.gov NCT03428477: https://clinicaltrials.gov/study/NCT03428477

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03428477.json