# iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

Source: https://onco.cc/trials/nct03608631/  
OnCo record `nct03608631` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in pancreatic cancer, run by M.D. Anderson Cancer Center, now recruiting.

## Summary

iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation is a phase 1/2, interventional study registered as NCT03608631 by M.D. Anderson Cancer Center, with a registry enrolment figure of 28 participants, started 2021-01-27 and due to reach its primary completion in 2027-04-30. Interventions recorded: Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA. Conditions listed: KRAS NP_004976.2:p.G12D; Metastatic Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8. Primary outcome: Maximum Tolerated Dose Determined by Dose Limiting Toxicity; Minimal residual disease rate in high-risk patients; Overall survival (OS). Pancreatic eligibility wording from the registry: "* Patients with histologically confirmed metastatic pancreatic ductal adenocarcinoma harboring KrasG12D mutation". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT03608631
- Phase: 1/2
- Setting: Phase I Study of Mesenchymal Stromal Cells-Derived Exosomes With KrasG12D siRNA for Metastatic Pancreas Cancer Patients Harboring KrasG12D Mutation
- Sponsor: M.D. Anderson Cancer Center
- Enrolled: 28

## Sources

- ClinicalTrials.gov NCT03608631: https://clinicaltrials.gov/study/NCT03608631

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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