# PD-1 Inhibitor and Chemotherapy With Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer

Source: https://onco.cc/trials/nct03774732/  
OnCo record `nct03774732` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of pembrolizumab in lung cancer, run by UNICANCER, active but no longer recruiting.

## Summary

PD-1 Inhibitor and Chemotherapy With Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT03774732 by UNICANCER, with a registry enrolment figure of 327 participants, started 2018-01-24 and due to reach its primary completion in 2026-12-22. Interventions recorded: Radiotherapy; Pembrolizumab; Chemotherapy. Conditions listed: Non Small Cell Lung Cancer; Non Small Cell Lung Cancer Metastatic; Non-Small Cell Carcinoma of Lung, TNM Stage 4. Primary outcome: 1-year Overall Survival. Lung eligibility wording from the registry: "Histologically or cytologically confirmed advanced (stage IIIB/IIIC/IV), squamous or non-squamous NSCLC". Sites: France, Monaco. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-25
- Also known as: NIRVANA-LUNG
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT03774732
- Phase: 3
- Setting: PD-1 Inhibitor and Chemotherapy With Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer
- Sponsor: UNICANCER
- Enrolled: 327

## Sources

- ClinicalTrials.gov NCT03774732: https://clinicaltrials.gov/study/NCT03774732

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- companies: [UNICANCER](https://onco.cc/companies/unicancer/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct03774732.json