# Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer

Source: https://onco.cc/trials/nct03803553/  
OnCo record `nct03803553` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of encorafenib, binimetinib, trastuzumab and pertuzumab in colorectal cancer, run by Massachusetts General Hospital, active but no longer recruiting.

## Summary

Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer is a phase 3, randomised interventional study registered as NCT03803553 by Massachusetts General Hospital, with a registry enrolment figure of 400 participants, started 2020-04-16 and due to reach its primary completion in 2026-12. Interventions recorded: FOLFIRI Protocol; ACTIVE SURVEILLANCE; Nivolumab Protocol; Encorafenib/Binimetinib/Cetuximab Protocol; Trastuzumab + Pertuzumab. Conditions listed: Metastatic Colon Cancer; Stage III Colon Cancer. Primary outcome: Disease-free survival (DFS); Clearance rate of ctDNA. Colorectal eligibility wording from the registry: "* Participants must have histologically confirmed resected Stage III adenocarcinoma of the colon". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03803553
- Phase: 3
- Setting: Early Identification and Treatment of Occult Metastatic Disease in Stage III Colon Cancer
- Sponsor: Massachusetts General Hospital
- Enrolled: 400

## Sources

- ClinicalTrials.gov NCT03803553: https://clinicaltrials.gov/study/NCT03803553

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Monoclonal antibodies](https://onco.cc/technologies/monoclonal-antibody/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Binimetinib](https://onco.cc/drugs/binimetinib/), [Encorafenib](https://onco.cc/drugs/encorafenib/), [Pertuzumab](https://onco.cc/drugs/pertuzumab/), [Trastuzumab](https://onco.cc/drugs/trastuzumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03803553.json