# Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Source: https://onco.cc/trials/nct03850574/  
OnCo record `nct03850574` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Venetoclax and Azacitidine in myelodysplastic syndromes / neoplasms and chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, run by Aptose Biosciences Inc., now recruiting.

## Summary

Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia is a phase 1/2 interventional study registered as NCT03850574 by Aptose Biosciences Inc., with 240 participants planned, started 2019-03-11 and due to reach its primary completion in 2026-11. Interventions recorded: Tuspetinib, Venetoclax Oral Tablet and Azacitidine for Intravenous Infusion.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT03850574
- Phase: 1/2
- Setting: A Phase 1/2 Open Label, Multicenter, Dose Escalation and Expansion Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)
- Sponsor: Aptose Biosciences Inc.
- Enrolled: 240

## Sources

- ClinicalTrials.gov NCT03850574: https://clinicaltrials.gov/study/NCT03850574

## Connected records

- cancers: [Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms](https://onco.cc/cancers/cmml/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)
- drugs: [Azacitidine](https://onco.cc/drugs/azacitidine/), [Tuspetinib](https://onco.cc/drugs/tuspetinib/), [Venetoclax](https://onco.cc/drugs/venetoclax/)
- companies: [Aptose Biosciences](https://onco.cc/companies/aptose/)

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