# Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer

Source: https://onco.cc/trials/nct03875781/  
OnCo record `nct03875781` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Assistance Publique - Hôpitaux de Paris, now recruiting.

## Summary

Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer is a phase 3, randomised interventional study registered as NCT03875781 by Assistance Publique - Hôpitaux de Paris, with a registry enrolment figure of 540 participants, started 2019-06-05 and due to reach its primary completion in 2026-12-05. Interventions recorded: Chemotherapy; Radiochemotherapy. Conditions listed: Rectal Cancer; Advanced Cancer. Primary outcome: Survival. Colorectal eligibility wording from the registry: "* Histologically proven middle or low rectal carcinoma, ≤ 10 cm from the anal verge on MRI (sagittal slide)". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NORAD01
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03875781
- Phase: 3
- Setting: Non Inferiority Multicenter Phase III Randomized Trial Comparing Preoperative Chemotherapy Only to Chemotherapy Followed by Chemoradiotherapy for Locally Advanced Resectable Rectal Cancer (Intergroup FRENCH-GRECCAR- PRODIGE)
- Sponsor: Assistance Publique - Hôpitaux de Paris
- Enrolled: 540

## Sources

- ClinicalTrials.gov NCT03875781: https://clinicaltrials.gov/study/NCT03875781

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03875781.json