# Colorectal Metastasis Prevention International Trial 2

Source: https://onco.cc/trials/nct03919461/  
OnCo record `nct03919461` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of propranolol (Hemangeol) in colorectal cancer, run by Assaf-Harofeh Medical Center, now recruiting.

## Summary

Colorectal Metastasis Prevention International Trial 2 is a phase 2, randomised interventional study registered as NCT03919461 by Assaf-Harofeh Medical Center, with a registry enrolment figure of 200 participants, started 2019-02-28 and due to reach its primary completion in 2027-02-28. Interventions recorded: Propranolol and etodolac; Placebo. Conditions listed: Colorectal Neoplasms. Primary outcome: 5-year disease-free-survival; Biomarkers in extracted tumor tissue samples assessing pro- and anti-metastatic processes; Biomarkers in blood samples assessing pro- and anti-metastatic processes. Colorectal eligibility wording from the registry: "Patients planned for surgery for primary resection of colon or rectal cancer with curative intent". Sites: Israel. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: COMPIT-2
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03919461
- Phase: 2
- Setting: Perioperative Use of a β-adrenergic Blocker, Propranolol, and a COX2 Inhibitor, Etodolac, in Patients Undergoing Resection With Curative Intent for Primary Colon and Rectal Cancer: Effect on Tumor Recurrence and Survival
- Sponsor: Assaf-Harofeh Medical Center
- Enrolled: 200

## Sources

- ClinicalTrials.gov NCT03919461: https://clinicaltrials.gov/study/NCT03919461

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Propranolol (Hemangeol)](https://onco.cc/drugs/propranolol-hemangeol/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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