# Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer

Source: https://onco.cc/trials/nct03926338/  
OnCo record `nct03926338` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of toripalimab in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer is a phase 2, randomised interventional study registered as NCT03926338 by Sun Yat-sen University, with a registry enrolment figure of 270 participants, started 2019-05-10 and due to reach its primary completion in 2027-04-01. Interventions recorded: Neoadjuvant toripalimab plus celecoxib for 6 cycles; Neoadjuvant toripalimab monotherapy for 6 cycles; Neoadjuvant toripalimab plus celecoxib for 12 cycles; Neoadjuvant toripalimab monotherapy for 12 cycles; Toripalimab plus celecoxib as neoadjuvant or definitive therapy. Conditions listed: Colorectal Cancer; Mismatch Repair-deficient (dMMR); Microsatellite Instability-high (MSI-H); Neoadjuvant Therapy. Primary outcome: Pathological complete response (pCR) rates (PICC-1 and PICC-2 cohorts); Event-free survival (EFS) (PICC-3 cohort). Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the colon or rectum". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PICC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03926338
- Phase: 2
- Setting: Neoadjuvant PD-1 Blockade by Toripalimab With or Without Celecoxib in Mismatch-repair Deficient or Microsatellite Instability-high Locally Advanced Colorectal Cancer (PICC)
- Sponsor: Sun Yat-sen University
- Enrolled: 270

## Sources

- ClinicalTrials.gov NCT03926338: https://clinicaltrials.gov/study/NCT03926338

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Toripalimab](https://onco.cc/drugs/toripalimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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