# Assessment of Direct Biomarkers of Aspirin Action to Develop a Precision Chemoprevention Therapy of Colorectal Cancer

Source: https://onco.cc/trials/nct03957902/  
OnCo record `nct03957902` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of aspirin in colorectal cancer, run by Instituto de Investigación Sanitaria Aragón, now recruiting.

## Summary

Assessment of Direct Biomarkers of Aspirin Action to Develop a Precision Chemoprevention Therapy of Colorectal Cancer is a phase 2, randomised interventional study registered as NCT03957902 by Instituto de Investigación Sanitaria Aragón, with a registry enrolment figure of 60 participants, started 2019-05-06 and due to reach its primary completion in 2025-05. Interventions recorded: acetylsalicylic acid. Conditions listed: Colorectal Cancer. Primary outcome: Assessment of changes in acetylation levels of COX enzymes in platelets and non-neoplastic and neoplastic colonic tissues. Colorectal eligibility wording from the registry: "* recent diagnosis (\< 48h) of rectum or colon cancer, established by endoscopy and later confirmed by anatomo-pathologic study". Sites: Spain. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03957902
- Phase: 2
- Setting: Assessment of Direct Biomarkers of Aspirin Action to Develop a Precision Chemoprevention Therapy of Colorectal Cancer
- Sponsor: Instituto de Investigación Sanitaria Aragón
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT03957902: https://clinicaltrials.gov/study/NCT03957902

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Aspirin](https://onco.cc/drugs/aspirin/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03957902.json