# Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct03975049/  
OnCo record `nct03975049` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, not yet recruiting.

## Summary

Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT03975049 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 933 participants, started 2019-08 and due to reach its primary completion in 2024-07. Interventions recorded: Chemoradiation; FOLFOXIRI Protocol; Folfox Protocol. Conditions listed: Rectal Cancer; Chemotherapy Effect. Primary outcome: Disease-free survival. Colorectal eligibility wording from the registry: "* 2）Histological diagnosis of rectal adenocarcinoma;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT03975049
- Phase: 3
- Setting: A Prospectively Randomized Phase III Trial Comparing Short-term mFOLFOXIRI, Long-term mFOLFOX6 and Traditional Chemoradiation as Preoperative Neoadjuvant Therapy for Locally Advanced Rectal Cancer
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 933

## Sources

- ClinicalTrials.gov NCT03975049: https://clinicaltrials.gov/study/NCT03975049

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct03975049.json