# A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantl

Source: https://onco.cc/trials/nct04002297/  
OnCo record `nct04002297` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Zanubrutinib, Bendamustine, Rituximab in hodgkin lymphoma and mantle cell lymphoma, run by BeOne Medicines, active and no longer recruiting.

## Summary

A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation is a phase 3 interventional study registered as NCT04002297 by BeOne Medicines, with 510 participants enrolled, started 2019-08-20 and due to reach its primary completion in 2027-03. Interventions recorded: zanubrutinib, bendamustine, rituximab. Conditions listed: Mantle Cell Lymphoma; Non-Hodgkin Lymphoma. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04002297
- Phase: 3
- Setting: A Phase 3 Randomized, Open-Label, Multicenter Study Comparing Zanubrutinib (BGB-3111) Plus Rituximab Versus Bendamustine Plus Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
- Sponsor: BeOne Medicines
- Enrolled: 510

## Sources

- ClinicalTrials.gov NCT04002297: https://clinicaltrials.gov/study/NCT04002297

## Connected records

- cancers: [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Mantle cell lymphoma](https://onco.cc/cancers/mantle-cell-lymphoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)
- drugs: [Bendamustine](https://onco.cc/drugs/bendamustine/), [Rituximab](https://onco.cc/drugs/rituximab/), [Zanubrutinib](https://onco.cc/drugs/zanubrutinib/)
- companies: [BeOne Medicines (formerly BeiGene)](https://onco.cc/companies/beone/)

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