# Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer

Source: https://onco.cc/trials/nct04082364/  
OnCo record `nct04082364` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of Margetuximab, Retifanlimab and Trastuzumab in HER2-positive gastric cancer, run by MacroGenics, completed.

## Summary

Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer is a phase 2/3 interventional study registered as NCT04082364 by MacroGenics, with 82 participants recorded, started 2019-09-30 and reaching its primary completion in 2024-01-15. Interventions recorded: margetuximab, Retifanlimab, Tebotelimab, Trastuzumab, Chemotherapy. Conditions recorded: Gastric Cancer, Gastroesophageal Junction Cancer, HER2-positive Gastric Cancer.

Linked to the drug Margetuximab because the registry names it among its interventions and HER2-positive gastric cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT04082364
- Phase: 2/3
- Setting: A Phase 2/3 Trial to Evaluate Margetuximab in Combination With INCMGA00012 and Chemotherapy or MGD013 and Chemotherapy in Patients With Metastatic or Locally Advanced, Treatment-naïve, HER2-Positive Gastric or Gastroesophageal Junction Cancer
- Sponsor: MacroGenics
- Enrolled: 82

## Sources

- ClinicalTrials.gov NCT04082364: https://clinicaltrials.gov/study/NCT04082364

## Connected records

- cancers: [HER2-positive gastric cancer](https://onco.cc/cancers/gastric-her2-positive/)
- drugs: [Margetuximab](https://onco.cc/drugs/margetuximab/), [Retifanlimab](https://onco.cc/drugs/retifanlimab/), [Trastuzumab](https://onco.cc/drugs/trastuzumab/)
- companies: [MacroGenics](https://onco.cc/companies/macrogenics/)

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