# Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct04094688/  
OnCo record `nct04094688` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of bevacizumab (glioblastoma use), fOLFOX (5-FU, leucovorin, oxaliplatin), leucovorin (folinic acid), fluorouracil (5-FU) and other drugs in colorectal cancer, run by Alliance for Clinical Trials in Oncology, active but no longer recruiting.

## Summary

Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT04094688 by Alliance for Clinical Trials in Oncology, with a registry enrolment figure of 455 participants, started 2019-10-29 and due to reach its primary completion in 2024-07-15. Interventions recorded: Bevacizumab; Oxaliplatin; Leucovorin Calcium; Fluorouracil; Irinotecan Hydrochloride; Irinotecan; Cholecalciferol; Quality-of-Life Assessment; Questionnaire Administration. Conditions listed: Colorectal Adenocarcinoma. Primary outcome: Progression-free Survival (PFS). Colorectal eligibility wording from the registry: "* Histologically confirmed advanced/metastatic colorectal adenocarcinoma for which metastasectomy is not planned". Sites: Puerto Rico, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: SOLARIS
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04094688
- Phase: 3
- Setting: Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients With Previously Untreated Metastatic Colorectal Cancer (SOLARIS)
- Sponsor: Alliance for Clinical Trials in Oncology
- Enrolled: 455

## Sources

- ClinicalTrials.gov NCT04094688: https://clinicaltrials.gov/study/NCT04094688

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Irinotecan (and liposomal irinotecan)](https://onco.cc/drugs/irinotecan/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)
- companies: [Alliance for Clinical Trials in Oncology](https://onco.cc/companies/alliance-oncology/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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