# Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients

Source: https://onco.cc/trials/nct04095299/  
OnCo record `nct04095299` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Vejle Hospital, now recruiting.

## Summary

Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients is a phase 3, randomised interventional study registered as NCT04095299 by Vejle Hospital, with a registry enrolment figure of 162 participants, started 2020-01-20 and due to reach its primary completion in 2026-12. Interventions recorded: 50.4 Gy to the tumor and elective volume; 62 Gy to the clinical tumor volume and 50.4 Gy to the elective volume; Capecitabine 825 mg/m2 twice daily on weekdays. Conditions listed: Cancer of Rectum. Primary outcome: Rectal preservation at two years. Colorectal eligibility wording from the registry: "* Histopathologically verified adenocarcinoma of the rectum". Sites: Denmark. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: WW3
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04095299
- Phase: 3
- Setting: Randomized Trial of Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy to Patients With Early Low and Mid Rectal Cancer: The Watchful Waiting 3 Trial (WW3)
- Sponsor: Vejle Hospital
- Enrolled: 162

## Sources

- ClinicalTrials.gov NCT04095299: https://clinicaltrials.gov/study/NCT04095299

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04095299.json